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KMID : 0363120070200010021
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Korean Journal of Pain
2007 Volume.20 No. 1 p.21 ~ p.25
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The Role of Opioid Receptor on the Analgesic Action of Intrathecal Sildenafil in Rats
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Lee Hyung-Gon
Jeong Chang-Yeong
Yoon Myung-Ha
Kim Woong-Mo
Shin Seung-Heon
Kim Yeo-Ok
Hwang Ran-Hee
Cui Jin-Hua
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Abstract
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Background: Intrathecal sildenafil has produced antinociception by increasing the cGMP through inhibition of phosphodiesterase 5. Spinal opioid receptor has been reported to be involved in the modulation of nociceptive transmission. The aim of this study was to examine the role of opioid receptor in the effect of sildenafil on the nociception evoked by formalin injection.
Methods: Rats were implanted with lumbar intrathecal catheters. Formalin testing was used as a nociceptive model. Formalin-induced nociceptive behavior (flinching response) was observed. To clarify the role of the opioid receptor for the analgesic action of sildenafil, naloxone was administered intrathecally 10 min before sildenafil delivery, and formalin was then injected 10 min later.
Results: Intrathecal sildenafil produced dose-dependent suppression of flinches in both phases during the formalin test. Intrathecal naloxone reversed the analgesic effect of sildenafil in both phases.
Conclusions: Sildenafil is active against the nociceptive state that’s evoked by a formalin stimulus, and the opioid receptor is involved in the analgesic action of sildenafil at thespinal level.(Korean J Pain 2007; 20: 21-25)
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KEYWORD
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analgesia, cyclic guanosine monophosphate, opioid receptor, phosphodiesterase, sildenafil, spinal cord.
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